The Missouri Department of Natural Resources describes a Hotel/ Motel business as:

A commercial establishment that offers rooms for rent that contain a bed, shower and toilet facilities to the general public for nightly rent on a short-term basis. 

You may need some or all of the following permits for a Hotel/ Motel business:

Asbestos Renovation and Demolition Notification https://dnr.mo.gov/air/asbestos-renovation-demolition-notification

Air

The department requires notification of demolitions and abatement projects involving regulated structures at least 10 working days before crews begin a project. To learn more, visit the department's Asbestos webpage.
Hazardous Waste/ Infectious Waste Transporter License https://dnr.mo.gov/waste-recycling/business-industry/permits-licenses-registrations/hazardous-waste-infectious-waste-transporter

Waste and Recycling

If you or your business plans to transport used oil, hazardous waste (combustible liquids, corrosives, poisons/ toxins, flammable liquids, flammable solids, PCB's) or infectious waste in Missouri, you are required to obtain a Hazardous Waste Transporter License.

Even though the request is approved by both Missouri Department of Transportation (MoDOT) and the Missouri Department of Natural Resources, you must apply for and renew the license through MoDOT. For more information, please visit MoDOT's Hazardous Waste Transport webpage.
Solid Waste Technician Certification https://dnr.mo.gov/waste-recycling/solid-waste-technician-certification

Waste and Recycling

Missouri solid waste disposal areas and solid waste processing facilities designated by rule, must be operated under the direction of a certified solid waste technician. For more information, please visit the department's Solid Waste Technician Certification webpage.